Pathophysiology of Ion Channels

Pathophysiology of Ion Channels

We are investigating the role of calcium ion channels in the development of human disorders so-called calcium channelopathies. Currently, most of our work is focused on one class of calcium channels so-called T-type channels.

Diversity of T-type calcium channels

On the one hand, we are investigating the molecular mechanisms as well as cell signaling pathways that control the expression and functioning of calcium channels and how these regulations are compromised and contribute to human disorders.

The T-type calcium channelosome.

On the other hand, we are analyzing the consequence and underlying mechanisms by which mutations in the genes encoding for calcium channels alter channel function to provide structure/function/phenotype information to inherited human channelopathies.

Cav3.2 channel mutations along with their associated syndromes. ASD, autism spectrum disorder; CP, chronic pain; GAeRS, genetic absence epilepsy rat from Strasburg; IGE, idiopathic generalised epilepsy; NMD, neuromuscular disorder; PA, primary aldosteronism.

Finally, we are developing new ion channel modulators for potential therapeutic use.

Surfen, a large spectrum calcium channel blocker with analgesic properties.

Our lab is part of the Department of Pathophysiology at the Third Faculty of Medicine of Charles University in Prague, Czech Republic.


Dr. Norbert Weiss, PhD

Principal Investigator


Department of Pathophysiology

Charles University - Third Faculty of Medicine

Ruska 87
10000 Prague 10
Czech Republic


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