Pathophysiology of Ion Channels
We are investigating the role of calcium ion channels in the development of human disorders so-called calcium channelopathies. Currently, most of our work is focused on one class of calcium channels so-called T-type channels.
On the one hand, we are investigating the molecular mechanisms as well as cell signaling pathways that control the expression and functioning of calcium channels and how these regulations are compromised and contribute to human disorders.
On the other hand, we are analyzing the consequence and underlying mechanisms by which mutations in the genes encoding for calcium channels alter channel function to provide structure/function/phenotype information to inherited human channelopathies.
Finally, we are developing new ion channel modulators for potential therapeutic use.
Our lab is part of the Department of Pathophysiology at the Third Faculty of Medicine of Charles University in Prague, Czech Republic.