Pathophysiology of Ion Channels

Pathologies of Calcium Channels

Norbert Weiss & Alexandra Koschak (2014)

About this book

Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies.

The editors, Norbert Weiss and Alexandra Koschak, have been extraordinary successful in bringing together so many of the major researchers in this rapidly expanding field. To have all this information in a single volume is a fantastic resource for both those workers actively involved in this exciting field and for those wishing to find out more about particular diseases. 

Sir Michael Berridge  

Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.


Sir Michael Berridge

Part 1. Pathologies of Voltage-gated Calcium Channels

Cav2.1 Channels and Migraine
Daniela Pietrobon

Ataxia and CACNA1A: Episodic or Progressive?
Stephanie Schorge, Kinya Ishikawa

Role of L-Type Ca2+ Channels in Sensory Cells
Alexandra Koschak, Alexandra Pinggera, Klaus Schicker, Jörg Striessnig
T-Type Calcium Channels and Epilepsy 
Stuart M. Cain, Michael E. Hildebrand, Terrance P. Snutch
T-Type Calcium Channels in Pain Neuronal Circuits
Amaury Francois, Anne Pizzoccaro, Sophie Laffray, Emmanuel Bourinet
Cav1.1 Channel and Hypokalemic Periodic Paralysis
Emma Matthews, Michael G. Hanna

Cav1.1 in Malignant Hyperthermia
Viktor Yarotskyy, Robert T. Dirksen

Ryanodine Receptor 1 and Associated Pathologies
Julien Fauré, Joël Lunardi, Nicole Monnier, Isabelle Marty
The Lambert-Eaton Myasthenic Syndrome 
Paul W. Wirtz, Maarten J. Titulaer, Jan J. G. M. Verschuuren

Part 2.  Pathologies of Transient Receptor Potential Channels

TRPM1 and Congenital Stationary Night Blindness
Shoichi Irie, Takahisa Furukawa

Alterations in TRPM2 and TRPM7 Functions in the Immune System Could Confer Susceptibility to Neurodegeneration
Meredith C. Hermosura

TRPML Channels and Mucolipidosis Type IV
Christian Grimm, Math P. Cuajungco

Transient Receptor Potential Channels and Pain
Alexandre Denadai-Souza, Nicolas Cenac

Hereditary Channelopathies Caused by TRPV4 Mutations
Jeremy M. Sullivan, Thomas E. Lloyd, Charlotte J. Sumner

TRPC Channels in Cardiac Hypertrophy
Nadine Kirschmer, Kristina Lorenz, Petra Eder-Negrin
Role of TRPC and Orai Channels in Vascular Remodeling
Michael Poteser, Sarah Krenn, Klaus Groschner

TRPP2 in Polycystic Kidney Disease
Andrew Streets, Albert Ong

TRPM6 and Hypomagnesaemia/Hypocalcaemia
Daniel Landau, Hanna Shalev

TRP Channels in Prostate Cancer
George Shapovalov, Roman Skryma, Natalia Prevarskaya

Pharmacology of TRPV Channels
Ulrich Wissenbach

Part 3. Pathologies of Ligand-Gated Calcium Channels

IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington’s and Alzheimer’s Diseases
Masayoshi Tada, Masatoyo Nishizawa, Osamu Onodera

RyR2 in Cardiac Disorders
Ineke Nederend, Christian van der Werf, Arthur A. M. Wilde
P2X Receptors and Pain
François Rassendren, Lauriane Ulmann
P2X7 in Bipolar and Depressive Disorders
Melissa L. Barron, Eryn L. Werry, Iain S. McGregor, Michael Kassiou
Targeting NMDA Receptors in Epilepsy
Mehdi Ghasemi, Ahmad Reza Dehpour

Nicotinic AChR in Congenital Myasthenic Syndromes
Francesca Grassi, Sergio Fucile

CatSper in Male Infertility
Takuya Nishigaki, Ana Laura González‐Cota, Gerardo José Orta Salazar

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