The WEISS Lab


Pathophysiology of Ion Channels

Five Year Publications


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2022


Cavβ surface charged residues contribute to the regulation of neuronal calcium channels


A. Tran-van-Minh, M. De Waard, N. Weiss


Molecular brain, 2022


Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels


Leos Cmarko, Robin N Stringer, Bohumila Jurkovicova-Tarabova, T. Vacík, Ľ. Lacinová, N. Weiss


Molecular brain, 2022


T‐type channels: A new route for calcium entry into platelets


N. Weiss


Journal of Thrombosis and Haemostasis , 2022


Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases


Q. Coquerel, Claire Legendre, J. Frangieh, S. D. Waard, J. Montnach, Leos Cmarko, J. Khoury, Charifat Said Hassane, D. Bréard, B. Siegler, Z. Fajloun, H. de Pomyers, K. Mabrouk, N. Weiss, D. Henrion, P. Richomme, C. Mattei, M. Waard, A. Le Ray, C. Legros


Molecules, 2022



2021


Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice


M. Montera, A. Goins, Leos Cmarko, N. Weiss, Karin N Westlund High, Sascha R. A. Alles


Channels, 2021


Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels


N. Weiss, G. Zamponi


Cellular and Molecular Neurobiology, 2021


De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy


Robin N Stringer, Bohumila Jurkovicova-Tarabova, I. A. Souza, J. Ibrahim, T. Vacík, W. Fathalla, J. Hertecant, G. Zamponi, Ľ. Lacinová, N. Weiss


Molecular brain, 2021



2020


A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity


Robin N Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, O. Haji-Ghassemi, Romane Idoux, A. Liashenko, I. A. Souza, Y. Rzhepetskyy, Ľ. Lacinová, F. van Petegem, G. Zamponi, R. Pamphlett, N. Weiss


Molecular Brain, 2020


Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels


Vendula Ficelova, I. A. Souza, Leos Cmarko, M. Gandini, Robin N Stringer, G. Zamponi, N. Weiss


Molecular brain, 2020



2019


A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.


Aisylu S Gaifullina, J. Lazniewska, E. Gerasimova, Gulshat Burkhanova, Y. Rzhepetskyy, A. Tomin, P. Rivas-Ramírez, Junting Huang, Leos Cmarko, G. Zamponi, G. Sitdikova, N. Weiss


Pain, 2019


Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels


Bohumila Jurkovicova-Tarabova, Leos Cmarko, R. Rehak, G. Zamponi, Ľ. Lacinová, N. Weiss


Molecular Brain, 2019


Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy


M. Carter, H. McMillan, A. Tomin, N. Weiss


Channels, 2019


T-type calcium channels: From molecule to therapeutic opportunities.


N. Weiss, G. Zamponi


The international journal of biochemistry & cell biology, 2019


Genetic T-type calcium channelopathies


N. Weiss, G. Zamponi


Journal of Medical Genetics, 2019


T-Type Channel Druggability at a Crossroads.


N. Weiss, G. Zamponi


ACS chemical neuroscience, 2019



2017


Glycosylation of voltage-gated calcium channels in health and disease.


J. Lazniewska, N. Weiss


Biochimica et biophysica acta. Biomembranes, 2017


The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels


J. Proft, Y. Rzhepetskyy, J. Lazniewska, F. Zhang, S. Cain, T. Snutch, G. Zamponi, N. Weiss


Scientific Reports, 2017


Trafficking of neuronal calcium channels


N. Weiss, G. Zamponi


Neuronal signaling, 2017


Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain


P. Rivas-Ramírez, V. M. Gadotti, G. Zamponi, N. Weiss


Pflügers Archiv - European Journal of Physiology, 2017



2016


Glycosylation of α2δ1 subunit: a sweet talk with Cav1.2 channels.


J. Lazniewska, N. Weiss


General physiology and biophysics, 2016


Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression


J. Lazniewska, Y. Rzhepetskyy, F. Zhang, G. Zamponi, N. Weiss


Pflügers Archiv - European Journal of Physiology, 2016


Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation


Katarína Ondáčová, M. Karmažínová, J. Lazniewska, N. Weiss, Ľ. Lacinová


Channels, 2016


It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells.


Ľ. Lacinová, N. Weiss


General physiology and biophysics, 2016


T-type channels: release a brake, engage a gear


N. Weiss, Ľ. Lacinová


Channels, 2016


A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane


Y. Rzhepetskyy, J. Lazniewska, J. Proft, M. Campiglio, B. Flucher, N. Weiss


Channels, 2016