Pathophysiology of Ion Channels

Five Year Publications

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Cavβ surface charged residues contribute to the regulation of neuronal calcium channels

A. Tran-van-Minh, M. De Waard, N. Weiss

Molecular brain, 2022

Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels

Leos Cmarko, Robin N Stringer, Bohumila Jurkovicova-Tarabova, T. Vacík, Ľ. Lacinová, N. Weiss

Molecular brain, 2022

T‐type channels: A new route for calcium entry into platelets

N. Weiss

Journal of Thrombosis and Haemostasis , 2022

Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases

Q. Coquerel, Claire Legendre, J. Frangieh, S. D. Waard, J. Montnach, Leos Cmarko, J. Khoury, Charifat Said Hassane, D. Bréard, B. Siegler, Z. Fajloun, H. de Pomyers, K. Mabrouk, N. Weiss, D. Henrion, P. Richomme, C. Mattei, M. Waard, A. Le Ray, C. Legros

Molecules, 2022


Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice

M. Montera, A. Goins, Leos Cmarko, N. Weiss, Karin N Westlund High, Sascha R. A. Alles

Channels, 2021

Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels

N. Weiss, G. Zamponi

Cellular and Molecular Neurobiology, 2021

De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy

Robin N Stringer, Bohumila Jurkovicova-Tarabova, I. A. Souza, J. Ibrahim, T. Vacík, W. Fathalla, J. Hertecant, G. Zamponi, Ľ. Lacinová, N. Weiss

Molecular brain, 2021


A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Robin N Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, O. Haji-Ghassemi, Romane Idoux, A. Liashenko, I. A. Souza, Y. Rzhepetskyy, Ľ. Lacinová, F. van Petegem, G. Zamponi, R. Pamphlett, N. Weiss

Molecular Brain, 2020

Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels

Vendula Ficelova, I. A. Souza, Leos Cmarko, M. Gandini, Robin N Stringer, G. Zamponi, N. Weiss

Molecular brain, 2020


A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.

Aisylu S Gaifullina, J. Lazniewska, E. Gerasimova, Gulshat Burkhanova, Y. Rzhepetskyy, A. Tomin, P. Rivas-Ramírez, Junting Huang, Leos Cmarko, G. Zamponi, G. Sitdikova, N. Weiss

Pain, 2019

Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels

Bohumila Jurkovicova-Tarabova, Leos Cmarko, R. Rehak, G. Zamponi, Ľ. Lacinová, N. Weiss

Molecular Brain, 2019

Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy

M. Carter, H. McMillan, A. Tomin, N. Weiss

Channels, 2019

T-type calcium channels: From molecule to therapeutic opportunities.

N. Weiss, G. Zamponi

The international journal of biochemistry & cell biology, 2019

Genetic T-type calcium channelopathies

N. Weiss, G. Zamponi

Journal of Medical Genetics, 2019

T-Type Channel Druggability at a Crossroads.

N. Weiss, G. Zamponi

ACS chemical neuroscience, 2019


Glycosylation of voltage-gated calcium channels in health and disease.

J. Lazniewska, N. Weiss

Biochimica et biophysica acta. Biomembranes, 2017

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels

J. Proft, Y. Rzhepetskyy, J. Lazniewska, F. Zhang, S. Cain, T. Snutch, G. Zamponi, N. Weiss

Scientific Reports, 2017

Trafficking of neuronal calcium channels

N. Weiss, G. Zamponi

Neuronal signaling, 2017

Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain

P. Rivas-Ramírez, V. M. Gadotti, G. Zamponi, N. Weiss

Pflügers Archiv - European Journal of Physiology, 2017


Glycosylation of α2δ1 subunit: a sweet talk with Cav1.2 channels.

J. Lazniewska, N. Weiss

General physiology and biophysics, 2016

Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression

J. Lazniewska, Y. Rzhepetskyy, F. Zhang, G. Zamponi, N. Weiss

Pflügers Archiv - European Journal of Physiology, 2016

Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation

Katarína Ondáčová, M. Karmažínová, J. Lazniewska, N. Weiss, Ľ. Lacinová

Channels, 2016

It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells.

Ľ. Lacinová, N. Weiss

General physiology and biophysics, 2016

T-type channels: release a brake, engage a gear

N. Weiss, Ľ. Lacinová

Channels, 2016

A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

Y. Rzhepetskyy, J. Lazniewska, J. Proft, M. Campiglio, B. Flucher, N. Weiss

Channels, 2016