The WEISS Lab


Pathophysiology of Ion Channels

T-type calcium channels: From molecule to therapeutic opportunities.


Journal article


N. Weiss, G. Zamponi
The international journal of biochemistry & cell biology, 2019

Semantic Scholar DOI PubMed
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APA
Weiss, N., & Zamponi, G. (2019). T-type calcium channels: From molecule to therapeutic opportunities. The International Journal of Biochemistry & Cell Biology.

Chicago/Turabian
Weiss, N., and G. Zamponi. “T-Type Calcium Channels: From Molecule to Therapeutic Opportunities.” The international journal of biochemistry & cell biology (2019).

MLA
Weiss, N., and G. Zamponi. “T-Type Calcium Channels: From Molecule to Therapeutic Opportunities.” The International Journal of Biochemistry & Cell Biology, 2019.


Abstract

T-type calcium channels serve an essential role in the functioning of the nervous system. They exhibit unique properties among voltage-gated calcium channels, and mediate specific roles in brain function. Over the recent years, it has come to light that a number of chronic neurological disorders arise from defects in T-type channel function. The question then arises as to whether T-type channels could represent a relevant druggable target. In this review, we introduce the diversity, molecular structure, and principal electrophysiological properties of T-type channels. Then, we highlight their role in neuronal development, and their pathophysiological role in the nervous system. Finally, we discuss the potential of T-type channels as therapeutic targets in light of recent advances in their pharmacopoeia.


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